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KMID : 0359020070350010001
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Korean Journal of Gastrointestinal Endoscopy
2007 Volume.35 No. 1 p.1 ~ p.5
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Comparison of the Eradication Rates of One-week Low-dose Triple Therapy with Standard-dose Triple Therapy for Helicobacter pylori Infection
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Paik Woo-Hyun
Kim Youn-Joo
Kim In-Kyoung
Lee Jae-Kyung
Lee Chang-Hyun
Chung Goh-Eun
Hong Kyoung-Sup
Park Young-Soo
Hwang Jin-Hyeok
Kim Jin-Wook
Jeong Sook-Hyang
Kim Na-Young
Lee Dong-Ho
Jung Hyun-Chae
Song In-Sung
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Abstract
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Background/Aims:We can expect to reduce costs and decrease adverse events by using low-dose triple therapy for H. pylori eradication. However, the efficacy of low-dose triple therapy for Koreans is questionable. In this study, we compared the efficacy of low-dose triple therapy with standard-dose triple therapy.
Methods:We enrolled 480 patients who were diagnosed as suffering with H. pylori infection via endoscopy with biopsy or CLO testing. Thirty patients were excluded due to malignancy or having undergone previous antibiotics medication. Two hundred and eighty patients received standard-dose triple therapy (pantoprazole 40 mg b.d, amoxicillin 1,000 mg b.d., and clarithromycin 500 mg b.d.), and 170 patients received low-dose triple therapy (pantoprazole 40 mg b.d., amoxicillin 750 mg b.d., and clarithromycin 250 mg b.d.). Eradication was evaluated 4∼6 weeks after administering the medication.
Results:The H. pylori eradication rate was 77.9% in the standard-dose group, and 74.7% in the low-dose group. There was no significant difference in the H. pylori eradication rate between the two groups (p=0.444). The adverse events were significantly more frequent in the standard-dose group. One patient each in both groups discontinued medication because of an adverse event.
Conclusions:The efficacy of low-dose therapy is similar to standard-dose therapy, and the adverse events are less frequent with low-dose therapy. This suggests that low-dose therapy would be preferred when considering the cost- benefit and low rate of adverse drug events.
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KEYWORD
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Helicobacter pylori, Eradication, Low dose, Triple therapy
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